Secretin as a Satiation Whisperer With the Potential to Turn into an Obesity-curbing Knight

Abstract The obesity pandemic requires effective preventative and therapeutic intervention strategies. Successful sustained treatment is currently limited to bariatric surgery. Modulating the release of gut hormones considered promising mimic surgery with its beneficial effects on food intake, body weight, blood glucose levels. peptide secretin was first molecule be termed a hormone; nevertheless, only recently has it been established as legitimate anorexigenic peptide. In contrast that crosstalk brain either directly or by afferent neuronal projections, mediates meal-associated brown fat thermogenesis induce meal termination, thereby qualifying this physiological mechanism an attractive, peripheral target for obesity. perspective, pivotal interest deepen our yet superficial knowledge roles well in energy balance weight regulation. Of note, emerging differences between cold-induced must taken into account. fact, there no correlation these 2 entities. addition, investigation potential hedonic-driven chronic using suitable application strategies overcome pharmacokinetic limitations will provide further insight influence balance. aim article review facts secretin’s metabolic effects, address prevailing gaps knowledge, overview opportunities challenges control.